The phase III study evaluating the efficacy and safety of Gattex or teduglutide of NPS Pharmaceuticals in patients with Adult Short Bowel Syndrome met primary efficacy endpoint.
- Teduglutide is the generic name of Gattex. Teduglutide is a novel, recombinant analog of human glucagon-like peptide 2.
- Glucagon-like peptide 2 is released by the L-cell of the ileum in the presence of food. Glucagon-like peptide 2 has been shown to stimulate the brush-border enzyme activities in the intestine. In addition, it has been shown to reduce the mucosal cell death in the intestine. Other effects such as increase the growth of the intestine as well as nutrient absorption have been observed.
- Teduglutide being an analog of human glucagon-like peptide 2 is hoped to do what the natural substances do. Patients with short bowel syndrome often have poor quality of life. They often are not